Haematopoiesis in the rat in riboflavin deficiency

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Effects of riboflavin deficiency on the synthesis of ester forms of riboflavin in the rat lens.

A few reports were found on the riboflavin (B2) in the eye tissues in various species (1-3). Flavin compound in the eye of Rana nigromaculata concentrates in the choroid, iris, ciliary body and is not present in other parts. The amount and distribution of flavin compound in the eye varies considerably in different species of frogs (4). The presence of B2 in the lens of haddock (Gadus aeglefinus...

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We have looked for effects of deficiency in hypoxanthine phosphoribosyl transferase (HPRT) in the mouse comparable to non-behavioural consequences of HPRT-deficiency in humans. HPRT-deficient humans show abnormalities in haematopoiesis and, in heterozygotes, there is strong selection in haematopoietic tissues against HPRT-deficient cells arising as a result of X-chromosome inactivation. We have...

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Application of Riboflavin-Deficient Rat Erythrocytes in the in Vitro Assay of Faba Bean Toxicity

Background: Faba bean toxicity (favism) is a common condition observed in our region. Objective: To develop a short and simple technique involving the use of riboflavin-deficient rats to test in vivo faba bean toxicity. Methods/Results: Sprague Dawley rats were maintained on a riboflavin-deficient diet and their vitamin B2 status was monitored by the assay of erythrocyte glutathione reductase (...

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Regulation of riboflavin-metabolizing enzymes in riboflavin deficiency.

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ژورنال

عنوان ژورنال: British Journal of Nutrition

سال: 1960

ISSN: 0007-1145,1475-2662

DOI: 10.1079/bjn19600029